Which side effect should a nurse educate a client about when taking prednisone?

When educating a client about taking prednisone, it is important to discuss fluid retention and weight gain as a significant side effect. Prednisone is a corticosteroid that can induce sodium retention, leading to increased body fluid and weight gain over time. This effect occurs due to the medication's ability to promote the reabsorption of sodium in the kidneys, which also results in the retention of water. These changes can be particularly concerning for individuals with pre-existing conditions like heart failure or hypertension, where fluid balance is critical.

Additionally, the impact of prednisone on metabolism can lead to changes in appetite, contributing further to weight gain. It's essential for clients to be aware of these potential side effects so they can monitor their weight and fluid intake and report any significant changes to their healthcare provider. This education helps ensure that clients can manage any side effects proactively while on prednisone therapy.