Which of the following is an effect of rifabutin that patients should be made aware of?

Rifabutin is an antibiotic that is often used to treat infections caused by Mycobacterium avium complex, among others. One important side effect of rifabutin that patients should be aware of is the change in the color of bodily fluids. Specifically, rifabutin can cause the sweat, urine, and tears to take on a brown-orange hue. This discoloration is due to the drug's chemical properties and is harmless, although it can be alarming to patients who are not informed about it beforehand.

By ensuring patients are educated about this side effect, healthcare providers can help prevent unnecessary worry or confusion regarding the changes they may observe in their bodily fluids. Awareness allows patients to differentiate these harmless effects from serious side effects that may require medical attention. The understanding of such effects is crucial for adherence to the medication regimen, as fear of side effects can lead to noncompliance.