Which of the following conditions is most common when using SSRIs?

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants that impact neurotransmitter systems in the brain, specifically by increasing serotonin levels. One of the most commonly reported side effects associated with SSRIs is sexual dysfunction. This can manifest as decreased libido, erectile dysfunction, delayed orgasm, or anorgasmia in both men and women.

The occurrence of sexual dysfunction is substantial enough that it can affect patient adherence to the medication, as many individuals may prioritize their sexual health and relationships over the benefits of managing their depressive or anxiety symptoms. This side effect varies in intensity among individuals and can be dose-dependent, leading to an important consideration for healthcare providers when prescribing SSRIs.

Other side effects, while possible, are less commonly reported. Dry skin is not typically associated with SSRIs, and weight loss can occur but usually reflects a more minor subset of patients experiencing this effect. Joint pain is not a recognized common side effect of SSRIs, making sexual dysfunction the most relevant and widespread concern for those undergoing treatment with these medications.