Which medication class is less commonly associated with gastrointestinal disturbances compared to SSRIs?

Beta-blockers are less commonly associated with gastrointestinal disturbances when compared to selective serotonin reuptake inhibitors (SSRIs). SSRIs are known to frequently cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea, particularly when treatment is initiated. This occurs due to their mechanism of increasing serotonin levels, which can stimulate the gastrointestinal tract.

In contrast, beta-blockers primarily work by blocking adrenergic receptors and do not typically affect serotonin levels or gastrointestinal motility to the same extent. While beta-blockers can have some side effects related to the gastrointestinal system, they are generally considered to have a lower incidence of such disturbances compared to SSRIs.

This distinction is important when considering medication options for patients who may have a history of gastrointestinal issues, as selecting a medication class with a lower risk of these side effects can enhance patient compliance and treatment outcomes.