What is a notable side effect of corticosteroids?

Corticosteroids are widely known for their various therapeutic applications in conditions such as inflammation, autoimmune diseases, and asthma. A prominent side effect associated with corticosteroid use is weight gain and increased blood glucose levels.

This occurs primarily due to corticosteroids' ability to stimulate appetite and alter metabolism. Increased appetite can lead to overeating, while the corticosteroids can induce insulin resistance, contributing to elevated blood glucose levels. These effects are particularly notable in long-term use of corticosteroids, as they can lead to conditions like Cushing's syndrome, characterized by weight gain and hyperglycemia.

The other options mention symptoms that are not typical side effects of corticosteroids. Severe hair loss and anxiety are more commonly associated with other medications or health conditions rather than corticosteroids. Severe fatigue and low blood pressure are also not typical outcomes and can indicate other underlying issues. Muscle spasms and joint pain are generally not recognized as adverse reactions related to corticosteroid use, making weight gain and increased blood glucose levels the most relevant side effects.