What is a common side effect of both SSRIs and SNRIs?

Sexual dysfunction is a well-documented and common side effect associated with both selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). These classes of antidepressants primarily work by modulating neurotransmitters in the brain—specifically serotonin and norepinephrine—this modulation can interfere with various aspects of sexual function, including libido, arousal, and the ability to achieve orgasm.

While other side effects like dry mouth, insomnia, and increased appetite may occur, they are not as universally experienced across both classes as sexual dysfunction is. For example, dry mouth may be more prevalent in certain medications rather than across all SSRIs and SNRIs. Insomnia can happen, but some patients might experience sedation instead, depending on the specific drug. Increased appetite is less commonly reported and varies based on individual response and specific medications. In contrast, sexual dysfunction is a recognizable and common issue with both SSRIs and SNRIs, making it the best choice in this context.