What is a common adverse effect associated with SSRIs?

Sexual dysfunction is a well-documented and common adverse effect associated with selective serotonin reuptake inhibitors (SSRIs). These medications increase the levels of serotonin in the brain, which can enhance mood and alleviate symptoms of depression and anxiety but may also interfere with the normal sexual response. Patients taking SSRIs often report issues such as decreased libido, delayed orgasm, or anorgasmia, which can be quite distressing and impact their quality of life.

While headache, fatigue, and weight gain can occur in some patients taking SSRIs, they are not as consistently reported as sexual dysfunction. Many individuals tolerate the other potential side effects better or may experience them less frequently compared to sexual issues, making sexual dysfunction a more significant and common concern for those on these medications. Understanding this effect is critical for healthcare providers in order to address patient concerns and consider treatment options that may mitigate these adverse effects or explore alternative antidepressants that may have a different side effect profile.