What instructions should the nurse give to a client taking oral ibandronate 150 mg monthly?

When taking oral ibandronate, it is crucial to follow specific instructions to enhance the medication's effectiveness and minimize potential side effects. The correct guidance is to take ibandronate on an empty stomach and remain upright for at least 60 minutes. This is because ibandronate belongs to a class of medications called bisphosphonates, which work by inhibiting bone resorption and decreasing the risk of fractures.

Taking it on an empty stomach ensures optimal absorption since food and certain beverages can significantly interfere with the drug's bioavailability. Remaining upright for 60 minutes after taking ibandronate helps reduce the risk of esophageal irritation or reflux, which can occur if the medication is taken while lying down or if the patient consumes food or drink too soon after administration. This precaution is essential for the safe intake of the medication and to improve its therapeutic effects.

The other options do not align with the recommendations for ibandronate. While taking the medication with a full glass of water is important for swallowing, it is not sufficient on its own without the requirement of being upright. Taking it at any time during the day disregards the need for an empty stomach, which is critical for absorption. Additionally, taking ibandronate