What gastrointestinal issue is commonly reported as a side effect of SSRIs?

Nausea is commonly reported as a side effect of selective serotonin reuptake inhibitors (SSRIs) due to their influence on serotonin levels in the gastrointestinal tract. Serotonin not only plays a crucial role in mood regulation in the central nervous system but also has a significant effect on gastrointestinal motility and function. When SSRIs increase the availability of serotonin, it can lead to heightened gastrointestinal sensitivity and disturbances, often resulting in symptoms such as nausea. This side effect is typically more pronounced during the initial stages of treatment as the body adjusts to the medication.

In contrast, while constipation, heartburn, and diarrhea can also occur with SSRIs, they are less frequently reported compared to nausea. Each individual's response to medications can vary widely, and not all patients will experience gastrointestinal side effects. However, nausea stands out as a particularly prevalent and well-documented issue associated with the use of SSRIs.